Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddingsArticle Published on 2023-12-012022-11-15 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] 치료제, [키워드] antiviral properties binding affinity cells Cheminformatics Compound compounds conducted coronavirus dataset dose-dependent inhibition drug design Drug discovery evaluate half-maximal inhibitory concentration in silico inhibitor inhibitory effect ligand-based drug design M pro Machine learning. machine-learning molecular protease Protease inhibitor screened selected thought Toxicity Virtual screening virus infectivity [DOI] 10.1080/14756366.2022.2132486 PMC 바로가기
Being a health care professional in the ICU serving patients with covid-19: A qualitative studyResearch article Published on 2023-01-012022-10-05 Journal: Heart & lung : the journal of critical care [Category] 치료기술, [키워드] Anxiety approach being Care conducted COVID-19 COVID-19 pandemic Experiences explain Health health care providers Healthcare provider hospitalized patient ICU Infectious disease information intensive care intensive care unit Invasion management Nurse objective pandemic Pandemics participant Patient physical Physicians Psychological receive recruit Research Result risk the epidemic Turkey with COVID-19 [DOI] 10.1016/j.hrtlng.2022.07.011 [Article Type] Research article
Quantifying the relationship between sub-population wastewater samples and community-wide SARS-CoV-2 seroprevalenceArticle Published on 2022-12-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis assessment average Community Concentration conducted convenience sampling correlated correlation COVID-19 Disease prevalence Epidemic epidemiological Epidemiology estimate Health incidence rate increase in indicate Infection inherent biases Participants Prevalence prevalence rate Randomized regression analysis robust SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 seroprevalence serological sewer Spread stratified Stratified randomized sampling the disease USA Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.158567 PMC 바로가기
Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysisReview Article Published on 2022-12-172022-10-27 Journal: Brain Communications [Category] COVID-19, [키워드] 95% confidence interval Anxiety Anxiety Disorder calculated chronic COVID syndrome CINAHL Cognitive impairment conducted consequence control group control groups controls COVID-19 COVID-19 hospitalization COVID-19 infection curated database disorder duration of follow-up Evidence fatigue Follow-up Frequency help heterogeneity Hospitalization indicate Infection Insomnia linear Long COVID management mental health Meta-analysis moderate neurological Neuropsychiatric neuropsychiatry pandemic patients peer-reviewed study persistent post-acute sequelae of COVID-19 post-traumatic Prevalence prevalent Psychological PsycINFO reported symptom searched severity Sleep disturbance Stress Subgroup analysis survivor Symptom Symptoms systematic review unique was measured [DOI] 10.1093/braincomms/fcab297 PMC 바로가기 [Article Type] Review Article
Interleukin-18 and COVID-19Original Paper Published on 2022-12-162022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval Analysis applied association conducted Coronavirus Disease (COVID)-19 COVID-19 cytokine estimate Evolutionary biology experimental design Exploratory analysis Genetic Genome-wide association study genome-wide significant hospitalised IFN Immunity interferon interferon gamma Interleukin-18 investigated less liberal lower risk Mendelian randomisation Odds ratio precursor predicted predictor predictors Prevent randomisation severe COVID-19 severity Standard deviation vulnerability was related with COVID-19 [DOI] 10.1017/S0950268821002636 PMC 바로가기 [Article Type] Original Paper
SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients면역 억제 환자의 SARS-CoV-2 발산 역학 및 전파Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjust analysed anatomic site characterized collected conducted coronavirus Diagnosis Diversity dominant E484K first positive fitness genetic change Genome genomic Host hosts household transmission Immunosuppressed immunosuppressed patient immunosuppressed patients in urine in vivo Infection Interaction knowledge long-term viral shedding mother mutate Mutation mutation dynamics N501Y occurred P681R Patient replicate residue residues SARS-CoV-2 SARS-CoV-2 evolution selective Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Spike protein spread to Substitution temporal dynamics Transmission two patients Urine variant variant of concern variants variants of concern virus whole genome Whole genome sequencing whole genome sequencing. whole-genome sequencing [DOI] 10.1080/21505594.2022.2101198 PMC 바로가기 [Article Type] Article
Potential interactions between antineoplastic agents and medicines used to treat Covid-19Article Published on 2022-12-012022-11-15 Journal: Journal of Oncology Pharmacy Practice [Category] 치료제, [키워드] accounted Affect antineoplastic agents antineoplastic drug Baricitinib benefit Cancer Chloroquine Combination conducted COVID-19 disease drug drug combinations drug-drug interaction Drug-drug interactions Drug–drug interactions drug–drug interactions. Health Hydroxychloroquine identify Interaction interaction effect interactions involved Lexicomp Medicine Modification outcomes Patient Patients with cancer pharmacokinetic pharmacological intervention plasma concentration Potential professional risk severity therapeutic treat Treatment tyrosine kinase inhibitor was increased [DOI] 10.1177/10781552211040494 PMC 바로가기
Omicron infections profile and vaccination status among 1881 liver transplant recipients: a multi-centre retrospective cohortArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome adverse event adverse events Breakthrough infection China clinical manifestation Cohort collected concerning conducted coronavirus Coronavirus disease 2019 COVID-19 COVID-19 vaccination decrease Efficacy enrolled fatigue feature grade 3 higher risk inactivated Inactivated vaccine Infection infections liver liver dysfunction Liver transplantation Mild myalgia occurred omicron participant Patient patients postoperative protection rate. recipient retrospective cohort Retrospective study Safe safety profile SARS-CoV-2 Seven vaccination Vaccine variant viral shedding were infected whole-virion SARS-CoV-2 vaccine [DOI] 10.1080/22221751.2022.2136535 PMC 바로가기
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
Mapping post-traumatic stress disorder symptoms and quality of life among residents of Wuhan, China after the COVID-19 outbreak: A network perspectiveResearch article Published on 2022-12-012022-10-05 Journal: Journal of affective disorders [Category] 진단, [키워드] approach Attention changes in checklist Chinese Civilian Community conducted connection covariates COVID-19 COVID-19 outbreak cross-sectional cross-sectional survey emotional examined Follow-up General population initial lack life limitation mapping mental health network analysis objective outbreak pandemic participant Perspective Post-traumatic stress disorder Post-traumatic stress disorder symptoms Quality Quality of life Result self-report measure Study design Symptom Version were measured World Health Organization Wuhan Wuhan residents Wuhan, China [DOI] 10.1016/j.jad.2022.08.074 [Article Type] Research article